Nicotinamide Mononucleotide (NMN): A Pillar of Natural Supplements for Longevity
Nicotinamide mononucleotide (NMN): vital in maintaining cellular functions
Nicotinamide Mononucleotide (NMN) presents itself as a significant advance in the field of natural supplements, offering promising prospects for longevity and the fight against anti-aging. As a direct precursor of NAD+ (Nicotinamide Adenine Dinucleotide), NMN plays a crucial role in the maintenance and repair of cellular functions, establishing itself as a pillar for a longer and healthier life.
Strengthening Cellular and Metabolic Function |
|
|
NMN helps increase levels of NAD+, an essential coenzyme involved in hundreds of metabolic processes. As we age, a decrease in NAD+ levels can lead to a reduction in cellular and metabolic vitality. NMN supplementation helps restore these levels, promoting better energy management, increased DNA repair, and improved mitochondrial function, all key factors in delaying the effects of aging. |
 |
Anti-Inflammatory Effects and Protection Against Diseases |
|
 |
NMN has shown impressive abilities to reduce systemic inflammation, a contributing factor to many chronic diseases and age-related conditions, such as cardiovascular disease, diabetes, and neurodegenerative disorders. By modulating inflammatory pathways and supporting the body's natural defense mechanisms, NMN can play a significant preventative role against these conditions. |
Neurological and Cognitive Health Support |
|
|
Research indicates that NMN may have beneficial effects on brain health, including improving cognitive function and providing protection against neurodegenerative diseases like Alzheimer's disease. By supporting NAD+ production, NMN helps maintain cellular energy and neuronal health, essential for optimal cognitive function. |
 |
SIDE EFFECTS |
LITTLE TOXIC EFFECTS |
|
NMN is considered safe and well tolerated when used as recommended. However, as with any supplement, it is essential to select products from reputable manufacturers to ensure quality and effectiveness. Human studies are still limited, so caution is advised, especially at high doses. |
NMN, as a precursor to NAD+, has not shown significant toxicity in studies available to date. Its safety profile in humans, although promising, requires more research for a complete understanding. |
Conclusion
Nicotinamide Mononucleotide (NMN) represents an exciting advancement for those looking to improve their health and extend their longevity. By supporting cellular function, fighting inflammation, and protecting against age-related diseases, NMN is positioned as a key supplement in the quest for a longer, healthier life. With research underway to fully explore its potential, NMN may well be one of the most promising components of current anti-aging strategies.
SOURCES:
Nadeeshani H., Li J., Ying T., Zhang B., Lu J. Nicotinamide mononucleotide (NMN) as an anti-aging health product-Promises and safety concerns. J.Adv. Res. 2022;37:267–278. doi: 10.1016/j.jare.2021.08.003.
Hong W., Mo F., Zhang Z., Huang M., Wei X. Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism. Forehead. Cell Dev. Biol. 2020;8:246. doi:10.3389/fcell.2020.00246.
Chen X., Amorim JA, Moustafa GA, Lee JJ, Yu Z., Ishihara K., Iesato Y., Barbisan P., Ueta T., Togka KA, et al. Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. Aging. 2020;12:24504–24521. doi: 10.18632/aging.202453
Lee D., Tomita Y., Miwa Y., Shinojima A., Ban N., Yamaguchi S., Nishioka K., Negishi K., Yoshino J., Kurihara T. Nicotinamide Mononucleotide Prevents Retinal Dysfunction in a Mouse Model of Retinal Ischemia/Reperfusion Injury. Int. J. Mol. Sci. 2022;23:11228. doi:10.3390/ijms231911228.
Shade C. The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule. Integrator Med. 2020;19:12–14.
Yoshino J., Baur JA, Imai SI NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018;27:513–528. doi: 10.1016/j.cmet.2017.11.002. -
Luo C., Ding W., Yang C., Zhang W., Liu X., Deng H. Nicotinamide Mononucleotide Administration Restores Redox Homeostasis via the Sirt3-Nrf2 Axis and Protects Aged Mice from Oxidative Stress-Induced Liver Injury. J. Proteome Res. 2022;21:1759–1770. doi: 10.1021/acs.jproteome.2c00167.
Pu Q., Guo XX, Hu JJ, Li AL, Li GG, Li XY Nicotinamide mononucleotide increases cell viability and restores tight junctions in high-glucose-treated human corneal epithelial cells via the SIRT1/Nrf2/HO-1 pathway. Biomed. Pharmacother. 2022;147:112659. doi: 10.1016/j.biopha.2022.112659.
Imai S. Diagnostic and therapeutic applications of a novel plasma metabolite, Nicotinamide Mononucleotide (NMN), for age-associated metabolic complications in humans. Longer Life Foundation 2011.