Quercetin: The Key Natural Supplement for Longevity and Anti-Inflammation

Introduction to Quercetin: A Natural Anti-Aging

Quercetin, a natural pigment found in many foods such as onion, capers, olive oil and certain legumes, is known for its exceptional anti-oxidant and anti-inflammatory properties. As a major component of natural supplements, it plays a crucial role in promoting longevity and preventing age-related diseases.

Quercetin and the Fight against Age-Related Pathologies
Scientific research has highlighted the effectiveness of quercetin in the fight against age-related pathologies. Its beneficial action on neurodegenerative diseases, such as Alzheimer's disease, is particularly notable. Quercetin promotes the reduction of amyloid β and tauopathies, thus improving learning performance and spatial memory.
Impact of Quercetin on Neurodegenerative and Cardiovascular Diseases
	In addition to its role in neuroprotection, quercetin offers a protective effect against cancers, particularly prostate cancer, and cardiovascular diseases. Its antioxidant activity intervenes on the signaling pathways essential to the regulation of apoptosis and cell migration, thus reducing the risk of cancer development.
Quercetin: A Weapon Against Cellular Aging and Metabolic Diseases
The ability of quercetin to reduce cellular senescence opens new perspectives in the treatment of skin and systemic aging. It also acts on AGEs, reducing the risk of metabolic diseases such as diabetes, which underlines its importance as a natural supplement for a second youth.

SIDE EFFECTS	LITTLE TOXIC EFFECTS
Quercetin is generally well tolerated, but as with any supplement, it is crucial to choose high-quality products. Although no significant toxicity has been reported in humans, excessive consumption may cause digestive discomfort in some people.	Quercetin, thanks to its antioxidant and anti-inflammatory properties, is considered safe for human consumption within the limits of appropriate use. Research has not demonstrated significant toxicity associated with its use.

Conclusion

Quercetin stands out as a promising natural supplement for improving longevity and fighting inflammation and age-related diseases. By incorporating this powerful antioxidant into our diet, we can take a proactive step toward living a longer, healthier life.

SOURCES:

Thornhill SM, Kelly AM. Natural treatment of perennial allergic rhinitis. Altern Med Rev. Review. 2000;5(5):448-54

Katske F, Shoskes DA, et al. Treatment of interstitial cystitis with a quercetin supplement. Tech Urol. 2001;7(1):44-6

Edwards RL, Lyon T, et al. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007;137(11):2405-11

Maria S-GA, Ignacio M-MJ, Ramírez-Pineda Jose R, Marisol LR, Edison O, Patricia C-GG. The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice. Neuropharmacology. 2015;93:134-145

Chang HC, Yang YR, Wang PS, Wang RY. Quercetin enhances exercise-mediated neuroprotective effects in brain ischemic rats. Med. Sci. Sports & Ex. 2014;46(10):1908-16

Hayakawa M, Itoh M et al. Quercetin reduces eIF2α phosphorylation by GADD34 induction. Neurobiol. Aging. 2015;36(9):2509-18

Nöthlings U, Murphy SP, et al. Flavonols and pancreatic cancer risk: the multiethnic cohort study. Am J Epidemiol. 2007;166(8):924-31

Nam JS, Sharma AR, Nguyen LT, Chakraborty C, Sharma G, Lee SS. Application of Bioactive Quercetin in Oncotherapy: From Nutrition to Nanomedicine (review). Molecules. 2016;21(1):108

Khurana S, Venkataraman K, Hollingsworth A, Piche M, Tai TC. Polyphenols: Benefits to the Cardiovascular System in Health and in Aging. Nutrients. 2013;5(10):3779-3827

Yang HH, Hwangbo K, Zheng MS et al. Quercetin-3-O-β-d-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells. Arch. Pharm. Res. 2014;37(9):1219-33

Chondrogianni N, Kapetan S, Chinou I, Vassilatou K, Papassideri K, Gonos ES. Anti-aging and rejuvenating effects of quercetin. Experimental Gerontology. 2010;45(10):763-71

Alam M, Ahmad I, Naseem I. Inhibitory effect of quercetin in the formation of advance glycation end products of human serum albumin: An in vitro and molecular interaction study. Int. J. Biol. Macromolecules. 2015;79:336-343

Giuliani C, Bucci I, Di Santo S, et al. The flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function. Food and Chemical Toxicology. 2014;66:23-29

X. Cai, Z. Fang, J. Dou, A. Yu, G. Zhai. Bioavailability of Quercetin: Problems and Promises. Current Medicinal Chemistry. 2013;20:2572-2582