Resveratrol: an anti-aging pro-sirtuin antioxidant

Resveratrol: an anti-aging pro-sirtuin antioxidant

Longévité, Molécules et longévité, Suppléments naturels personnalisés -

Resveratrol: a molecule with fascinating properties

Resveratrol is a polyphenol present in particular in black grapes which was initially noted for its cardioprotective virtues, then for its property to prevent the occurrence and development of cancer in vitro and in vivo . It then appeared that resveratrol was a molecule capable of activating the Sirt1 enzyme and that, through this, it made it possible to extend life expectancy in yeast and different organisms (nematodes, flies, fish).

A significant increase in healthy life expectancy was also observed in mice made obese by a diet too rich in calories. This lengthening involves the reduction of pathologies resulting from this diet (reduction of cardiovascular, metabolic, hepatic damage, etc.). An increase in healthy life expectancy is also observed in non-obese mice.

The known benefits of resveratrol

The benefits of resveratrol are diverse and hundreds of studies, mainly on animals, have been carried out and demonstrate several benefits helping to promote and protect our health. Among them, we can note the preventive effect on heart disease, diabetes, neurodegenerative diseases and cancer, the reduction of hypertension or the reduction of bad cholesterol.

Resveratrol is a powerful antioxidant that neutralizes free radicals and prevents them from damaging cells. Through two complementary actions, it protects the inner lining of the arteries against damage caused by free radicals and optimizes vasodilation by protecting the body's ability to produce nitric oxide.

A very effective antioxidant

A sirtuin activator

Sirtuins are a class of NAD-dependent enzymes that affect cellular metabolism by regulating the expression of certain genes. Resveratrol is an activator of sirtuin 1, encoded by the SIRT1 gene (a tumor suppressor), thus improving mitochondrial function and slowing the proliferation of certain cancers. This gene also controls the longevity of several animal species, including humans.

Resveratrol has therapeutic properties that can act in the treatment of heart diseases. It helps reduce LDL (bad cholesterol), prevent hardening of the arteries and maintain constant pressure.

Prevention of cardiovascular diseases

Cancer prevention

Several studies suggest that resveratrol acts in the prevention and treatment of cancer through the activation of certain genes, including p53.

Research indicates that resveratrol helps combat skin damage caused by UV radiation, through supplementation or applied by direct application. The Caudalie brand has decided to make it its flagship anti-wrinkle product.

Prevention of skin aging

Interest of resveratrol in the fight against aging

Resveratrol is a naturally synthesized polyphenol that serves as a defense barrier against fungal invasions in plants. It is found in the skin of grapes, wine (particularly red wine), blueberries, peanuts and Japanese knotweed.

How does it affect aging ?

In addition to the role resveratrol plays in preventing age-related diseases, other studies have been conducted over the past two decades establishing a direct relationship between resveratrol and prolonged lifespan. "Resveratrol would also act on aging by activating certain proteins involved in primary aging such as AMPK (AMP-activated protein kinase) and by reducing inflammatory factors NF-κ B (nuclear factor kappa B), TNFα (Tumor necrosis factor α) and IL-6 (interleukin 6), as well as the reduction of free radicals. Another publication in the prestigious journal Nature, identified a new mechanism of action (TyrRS-PARP-1) of resveratrol which. would be 1000 times more sensitive (activated at quantities 1000 times lower) than its known action on sirtuins. Research continues.

Side effects

Few toxic effects

Resveratrol has no known side effects, but since the actual percentage of resveratrol in supplement form can vary, it is very important to purchase supplements from a reputable source and follow the recommended dosage.

Resveratrol is an organic molecule that has a wide range of actions on health. No studies have revealed toxicity in humans. 1


1 Hadrien Vielle,

2 Éric Simard,